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January 1, 1970

Government In Talks With Glaxo Over Bird Flu Vacci…

Filed under: Uncategorized — Jenny @ 8:00 am
Government In Talks With Glaxo Over Bird Flu Vaccine

(Oct 30, 2006) LONDON - GlaxoSmithKline is in talks with the government about a nation-wide bird flu vaccination after signing a similar deal with Singapore, it was reported on Monday.

Chief Executive J. P. Garnier met Prime Minister Tony Blair and Chancellor Gordon Brown this month to discuss the possibility of stockpiling tens of millions of doses of the firm's H5N1 vaccine, the Times said, without citing sources.

Glaxo had already reached a deal with Singapore, the newspaper said without revealing any details.

The firm was also close to singing a contract with France and had spoken to the U.S. government about the possibility of a mass vaccination programme although no imminent decision was on the cards, the newspaper added.

A spokesman for Glaxo was not immediately available for comment.

Last week, Europe's biggest drugmaker said it expected to sign more contracts to supply governments with its experimental vaccine for humans following a deal with Switzerland.

The Swiss Federal Office of Public Health has ordered 8 million doses of the vaccine to protect its entire population in the event of an influenza pandemic, which many experts fear may be triggered by bird flu.

The vaccine has not yet won regulatory approval but Glaxo plans to file it with the European Medicines Agency by the end of 2006.

Britain's population is about 60 million while Singapore has a population of 4.4 million. (from Reuters)

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China denounces reported discovery of new bird flu strain as inaccurate

BEIJING (AP) - China's Agriculture Ministry on Thursday disputed a scientific study about a pervasive, newly discovered strain of bird flu in China, calling the report inaccurate.

The findings, released this week in the Proceedings of the National Academy of Sciences, said the new strain - called H5N1 Fujian-like - was found in almost all poultry outbreaks and some human cases in southern China and was now becoming prevalent in Hong Kong, Laos, Malaysia, and Thailand.

"China has taken note of the study about the variation of the bird flu virus in southern China published by an academic journal abroad," the ministry said in a statement read aloud to reporters at a Foreign Ministry briefing. "The comments they made do not conform with facts."

The Agriculture Ministry said H5N1 had been monitored in southern China since 2004 and that there had not been any significant mutations to the virus.

"The biological characteristics of the virus do not show apparent changes," said the statement.

The retort follows renewed criticism by the World Health Organization that the ministry has not shared bird flu samples with the international health body since 2004. Sharing is key in helping health experts track the diseases and ultimately develop vaccines.

The Agriculture Ministry defended its actions. "We have shared all the information related to bird flu virus and diseases to international organizations in a timely manner," the statement said.

The H5N1 flu has devastated poultry in China and several other southeast Asian countries and has claimed more than 150 human lives. Public health authorities fear that the virus will mutate into a form that can spread easily among people, raising the potential for a worldwide pandemic that could kill millions.

The study released in the journal Tuesday by Chinese and American scientists charted the spread of the new strain by testing geese and ducks found in live markets in six southern Chinese beginning in June 2005.

Over the course of the year, the new strain became more pervasive, the study said. Among the 108 samples taken from poultry in April and June 2006, 103 - or 95 per cent - were infected with the Fujian-like strain, the study said.

Filed under: Uncategorized — Jenny @ 8:00 am
Bird flu to remain major threat for next decade: UN



CAIRO - Avian influenza is likely to remain a significant global threat for animals and humans for the next decade, top UN coordinator David Nabarro said on Thursday.



“The virus is likely to be with us for the five or ten years to come,” he told AFP in an interview.



According to the UN’s health agency, the highly pathogenic H5N1 strain of the virus has been confirmed in 256 humans worldwide since the first outbreak in 2003. It was lethal in at least 152 cases.




Nabarro, who was tasked last year by the world body with containing the crisis, warned that the international community had to remain on high alert for the possible mutation of the virus into one communicable between humans.



“The risk of a mutation to cause pandemic is still very much there,” he said. “As long as the virus is present in birds, there will also be a threat of sporadic human infection, and a possibility of a mutation which would cause at the end of the day a pandemic.”



“Trying to estimate the potential mortality of a pandemic is very hard. What I’ve already said is that you could have of range of between five and 150 million” deaths, said Nabarro.



“It’s the reason why I do think we a have to put now plenty of energy towards a long term reform of the poultry farming techniques, in order to reduce the risks of human infection.”



Nabarro said frequent occurrences of sporadic human infections meant the virus would not be eliminated for some time, but he voiced his hope that efforts deployed to combat the virus in recent months would have increased preparedness for a pandemic.



“The difference now is that countries all over the world are much more geared up to deal with this phenomenon than they were a year ago. It gives me some hope that when the virus appears in a new country, it can be controlled,” he said.



On a recent visit to Cairo to attend a global health research forum, Nabarro praised the Egyptian authorities’ performance in handling the bird flu outbreak.



With seven lethal human cases in less than a year, Egypt is the hardest-hit non-Asian country. (AFP)

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China still reneging on bird flu data



(Nov 3, 2006) The WHO said its efforts to track the spread of bird flu have been complicated by the failure of China's Agriculture Ministry to share samples of a newly discovered strain of the virus.

Scientific research released this week said that the new strain, called H5N1 Fujian-like, had spread widely over the past year, being found in almost all poultry outbreaks and some human cases in China, and now becoming prevalent in Hong Kong, Laos, Malaysia and Thailand.

Despite that prevalence, the ministry has not given the WHO any samples of the new strain, said Julie Hall, an infectious disease expert at the WHO's Beijing office.

"There's a stark contrast between what we're hearing from the researchers and what the Ministry of Agriculture says," Hall said. "Unless the ministry tells us what's going on and shares viruses on a regular basis, we will be doing diagnostics on strains that are old."

While new strains of viruses emerge regularly, health experts need to know when one becomes dominant in order to develop methods to detect and fight the disease, Hall said.

The ministry's reluctance has been an ongoing source of aggravation at the WHO. International health experts have repeatedly complained about Chinese foot-dragging in cooperating on investigating emerging diseases like bird flu and the SARS virus.

Telephones at the Agriculture Ministry were not answered on Wednesday and it did not immediately respond to faxed questions.

Some countries are slow to share genetic information or samples of viruses because they fear they will be pushed aside in the global race to produce a lucrative vaccine.

"This is a new disease. Nobody knows how to tackle it, nobody in the world has all the answers," Hall said. "But if they share, then we will all gain from that."

She said the ministry has not shared bird flu virus samples from poultry since 2004, a key impediment in developing diagnostic tools and vaccines.

Released this week, the year-long study by Chinese and US scientists found that, since June last year, one out of every 30 geese and one out of every 30 ducks in live markets tested positive for H5N1 in six southern Chinese provinces.

In that same period, however, the ministry reported only three outbreaks in the same provinces, Hall said.

The study was conducted in Fujian, Guangdong, Guangxi, Guizhou, Yunnan and Hunan -- densely populated provinces where people live in close proximity to ducks, pigs and other farm animals, making the area a common breeding ground for flu viruses.

Out of 108 virus samples taken from infected poultry between April and June of this year, 103, or 95 percent, had the H5N1 Fujian-like strain, according to the results of the study reported in Tuesday's issue of Proceedings of the National Academy of Sciences.

The H5N1 flu has devastated poultry in China and several other Southeast Asian countries and has also claimed more than 150 human lives. Most of the people affected lived close to flocks of chickens or other poultry.

Public health authorities fear that the virus will mutate into a form that can spread easily among people, raising the potential for a worldwide pandemic that could kill millions. (taipeitimes.com)

Filed under: Uncategorized — Jenny @ 8:00 am
Indonesian bird flu cases 'far from pandemic'



(Nov. 9) Jakarta - Indonesia, which has the highest number of human bird flu infections and fatalities, was unlikely to be hit by a pandemic of the disease in the immediate future, an official has claimed.



"We are still far from a pandemic," said Bayu Krisnamurthi, the chief executive of the Indonesian National Committee for Avian Influenza Control and Pandemic Influenza Preparedness (Komnas FBPI).



However, he cautioned the possibility of a pandemic remained, as no one could predict how the H5N1 virus that caused the disease would mutate.



The Komnas FBPI, set up by presidential decree in March, coordinates government responses to H5N1 bird flu cases, which experts fear could mutate into a form that spreads easily between humans, setting off a global pandemic.



The vast majority of bird flu cases in Indonesia and elsewhere have occurred after contact with infected poultry.



Indonesia now has 72 confirmed cases of human bird flu infection, 55 of them fatal.



But Krisnamurthi said the ratio of confirmed cases compared to reported suspect cases was decreasing, from about 30 to 35 percent six months ago to currently about 14 percent.



He said although bird flu had been found in 30 of the country's 32 provinces, human infections were contained to nine provinces.



He said the ratio between confirmed cases and fatalities remained largely unchanged at about 75 percent, due to late treatment following late diagnosis, and limited health facilities. - Sapa-AFP
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